1 Primary reactions to penicillin antibiotics include rash, itching, nausea and vomiting, shortness of breath, and anaphylaxis.ĭespite the high population prevalence, 80% to 90% of those reporting a penicillin allergy will have a negative response to penicillin skin testing. Patient-reported allergy to penicillin antibiotics is a common scenario during health care encounters, with an estimated population prevalence of roughly 8% to 12%.
